Straightforward and Efficient Deuteration of Terminal Alkynes with Copper Catalysis
نویسندگان
چکیده
The mild and effective preparation of deuterated organic molecules is an active area research due to their important applications. Herein, we report air-stable easy access copper(I) complex as catalyst for the deuteration mono-substituted alkynes. Reactions were carried out in technical solvents presence air, obtain excellent deuterium incorporation a range functionalised
منابع مشابه
Copper-catalyzed dehydrogenative borylation of terminal alkynes with pinacolborane.
LCuOTf complexes [L = cyclic (alkyl)(amino)carbenes (CAACs) or N-heterocyclic carbenes (NHCs)] selectively promote the dehydrogenative borylation of C(sp)-H bonds at room temperature. It is shown that σ,π-bis(copper) acetylide and copper hydride complexes are the key catalytic species.
متن کاملCopper-catalyzed aerobic oxidative amidation of terminal alkynes: efficient synthesis of ynamides.
A copper-catalyzed method for the preparation of ynamides has been identified that proceeds via aerobic oxidative coupling of terminal alkynes with various nitrogen nucleophiles, including cyclic carbamates, amides and ureas, and N-alkyl-arylsulfonamides and indoles.
متن کاملEfficient hydration of alkynes through acid-assisted Brønsted acid catalysis.
The combined acid catalyzed hydration of alkynes is an efficient one-step synthesis of carbonyl compounds. This atom-economical method is effective with a wide range of substrates, and the products are obtained in very good yields with low catalyst loading (0.2%). Furthermore, solid acids like Nafion were also efficient and could be easily recycled multiple times without loss of reactivity.
متن کاملEfficient merging of copper and photoredox catalysis for the asymmetric cross-dehydrogenative-coupling of alkynes and tetrahydroisoquinolines.
A highly efficient catalytic asymmetric alkynylation of prochiral CH2 groups in tetrahydroisoquinoline was developed using copper catalyzed cross-dehydrogenative-coupling of sp(3) and sp C-H bonds with the assistance of a photocatalyst and visible light.
متن کاملLigand-, copper-, and amine-free sonogashira reaction of aryl iodides and bromides with terminal alkynes.
Conditions for an efficient ligand-, copper-, and amine-free palladium-catalyzed Sonogashira reaction of aryl iodides and bromides with terminal alkynes have been developed. Critical to the success of this new protocol is the use of tetrabutylammonium acetate as the base. Noteworthy features of this method are room-temperature conditions and the tolerance of a broad range of functional groups i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Catalysts
سال: 2023
ISSN: ['2073-4344']
DOI: https://doi.org/10.3390/catal13040648